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Image Search Results
Journal: Biological psychiatry. Cognitive neuroscience and neuroimaging
Article Title: Transcranial Direct Current Stimulation Applied to the Dorsolateral and Ventromedial Prefrontal Cortices in Smokers Modifies Cognitive Circuits Implicated in the Nicotine Withdrawal Syndrome
doi: 10.1016/j.bpsc.2019.12.020
Figure Lengend Snippet: (A) Experimental Design. Double-blinded, randomized, sham-controlled crossover study completed by both smokers (“Smoker timeline”) and nonsmokers (“Nonsmoker timeline”). All subjects completed three tDCS-fMRI sessions, randomized between the three tDCS conditions (part B of this figure). Smokers completed each visit following biochemically verified (CO monitor) 12-hours overnight nicotine abstinence, and placed a study patch, containing either nicotine or placebo, in the morning at least 2 hours prior to the first scan of the day. All conditions (study patch, tDCS condition) were randomized and counterbalanced. On the second visit day, the tDCS conditions were re-randomized for smoker participants. Subjects completed multiple simultaneous fMRI scans before, during and after tDCS, in a fixed order (“tDCS-fMRI session: scan order”). tDCS sessions were separated by at least a 90-minute inter-tDCS period (equating to an inter-scan interval – the time spent outside of the scanner between the end of one MRI session and start of another – of at least ~30–45 minutes). Each tDCS-fMRI scan lasted between 60 and 90 minutes. The study visit day (with 3 tDCS-fMRI sessions) lasted ~7–8 hours, including pre-MRI nursing assessments, task training and questionnaires. In some cases of equipment or participant scheduling issues, some tDCS sessions were separated by a number of days. The counterbalance conditions were determined by the NIDA-IRP Pharmacy and kept blinded there, with tDCS setting programmed by the MR-operator according to a key. Note that subjects performed the N-back twice, both during and after stimulation. Here, we report only the N-back online (during). A DTI scan was taken once per participant, at the end of one of the tDCS-fMRI scan sessions. Note: “tDCS-fMRI session: scan order” panel applies to all tDCS-fMRI sessions.
Article Snippet: Transcranial Direct Current Stimulation Subjects completed 3
Techniques: